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Sacubitril and valsartan

Brand names: Entresto

Sacubitril-valsartan (Entresto) helps people with heart failure live longer and stay out of the hospital.

Brand namesEntresto
Type of medicineHeart failure medicine (ARNI)
Prescription?Prescription
ImportantThis page is general information, not a prescription. Don't start, stop, or change a medicine without talking to your provider or pharmacist.

Overview

It combines valsartan (an ARB) with sacubitril, which helps the body get rid of extra salt and water.

What it's used for

  • Heart failure
  • Heart failure in children

How to take it

  • Take it twice a day, with or without food.
  • If switching from an ACE inhibitor, stop the ACE inhibitor at least 36 hours before the first dose.

Your dose depends on your health and other medicines. Always follow your prescription label, and ask your pharmacist if anything is unclear.

Side effects

Common side effects

  • Dizziness
  • Low blood pressure
  • Cough
  • High potassium
Call 911Swelling of the face, lips, tongue, or throat, or trouble breathing (can happen even after years of use)
Call your provider todayFainting or severe dizziness
Call your provider todayMuscle weakness or a slow or irregular heartbeat (possible high potassium)
Call your provider todayPeeing much less than usual

Warnings

  • Do not take during pregnancy; it can harm an unborn baby.
  • Your provider will check kidney function and potassium.
  • Not for people who've had angioedema.

Other medicines, foods, and alcohol

  • Never take with an ACE inhibitor (wait 36 hours between).
  • Potassium supplements and salt substitutes can raise potassium too high.
  • NSAIDs can harm the kidneys.
  • Lithium levels can rise.

Tell your provider and pharmacist about every medicine, vitamin, and supplement you take.

Pregnancy and breastfeeding

Don't take it if you are pregnant. If you become pregnant, call your provider right away to switch medicines.

Missed doses, overdose, and storage

If you miss a dose

Take it as soon as you remember, unless it's almost time for your next dose. Then skip the missed dose. Don't take two doses at once.

If someone takes too much

Call Poison Control at 1-800-222-1222 or get help online at poison.org. Call 911 if the person collapses, has a seizure, has trouble breathing, or can't be woken.

Storing it

Store at room temperature, away from heat and moisture (not in the bathroom), and out of reach of children and pets.

Conditions it's used for

Sources

Last updated 2026-11-13.