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Silver sulfadiazine

Brand names: Silvadene, SSD

Silver sulfadiazine is a prescription cream that helps prevent infection in second- and third-degree burns.

Brand namesSilvadene, SSD
Type of medicineBurn cream (antibiotic)
Prescription?Prescription
ImportantThis page is general information, not a prescription. Don't start, stop, or change a medicine without talking to your provider or pharmacist.

Overview

Minor burns usually heal with simple care; deep or large burns need medical treatment.

What it's used for

  • Preventing infection in serious burns

How to take it

  • Clean the burn and apply a thin layer (about 1/16 inch) once or twice a day with a clean glove.
  • Keep the burn covered with cream at all times.

Your dose depends on your health and other medicines. Always follow your prescription label, and ask your pharmacist if anything is unclear.

Side effects

Common side effects

  • Burning or itching
  • Skin discoloration
Call your provider todayFever, spreading redness, or pus around the burn
Call your provider todayUnusual bruising, fever, or sore throat (low white blood cells)
Call 911A blistering, peeling, or widespread red rash, especially with fever

Warnings

  • Not for people allergic to sulfa drugs.
  • Not for newborns under 2 months or late pregnancy.
  • Get medical care for burns larger than your palm, on the face, hands, feet, groin, or joints, or that are white, leathery, or charred.

Other medicines, foods, and alcohol

  • It may inactivate some wound enzyme treatments.

Tell your provider and pharmacist about every medicine, vitamin, and supplement you take.

Pregnancy and breastfeeding

Avoid near term. Ask your provider.

Missed doses, overdose, and storage

If you miss a dose

Apply it when you remember, then go back to your usual schedule. Don't apply extra to make up for it.

If someone takes too much

Call Poison Control at 1-800-222-1222 or get help online at poison.org. Call 911 if the person collapses, has a seizure, has trouble breathing, or can't be woken.

Storing it

Store at room temperature, away from heat and moisture (not in the bathroom), and out of reach of children and pets.

Conditions it's used for

Sources

Last updated 2026-11-13.