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Tacrolimus

Brand names: Prograf, Envarsus XR, Protopic (ointment)

Tacrolimus prevents organ transplant rejection. As an ointment, it treats eczema.

Brand namesPrograf, Envarsus XR, Protopic (ointment)
Type of medicineImmunosuppressant
Prescription?Prescription
ImportantThis page is general information, not a prescription. Don't start, stop, or change a medicine without talking to your provider or pharmacist.

Overview

Pills need regular blood level checks. The ointment is a non-steroid option for eczema on the face and skin folds.

What it's used for

  • Preventing rejection after kidney, liver, or heart transplant
  • Eczema (ointment)

How to take it

  • Pills: take at the same times every day, consistently with or without food.
  • Ointment: apply a thin layer twice a day to affected skin.

Your dose depends on your health and other medicines. Always follow your prescription label, and ask your pharmacist if anything is unclear.

Side effects

Common side effects

  • Shakiness
  • Headache
  • High blood pressure
  • Burning or itching (ointment)
Call your provider todayFever, chills, sore throat, or other signs of infection
Call your provider todayPeeing less or swelling (kidney problems)
Call your provider todayVery high blood sugar
Call 911Seizure, confusion, or vision changes

Warnings

  • Boxed warnings (pills): serious infections and some cancers.
  • Avoid sunlamps and limit sun on ointment-treated skin.

Other medicines, foods, and alcohol

  • Many medicines change its level, including some antibiotics, antifungals, seizure medicines, and grapefruit.

Tell your provider and pharmacist about every medicine, vitamin, and supplement you take.

Pregnancy and breastfeeding

Talk with your transplant team.

Missed doses, overdose, and storage

If you miss a dose

Take it as soon as you remember, unless it's almost time for your next dose. Then skip the missed dose. Don't take two doses at once.

If someone takes too much

Call Poison Control at 1-800-222-1222 or get help online at poison.org. Call 911 if the person collapses, has a seizure, has trouble breathing, or can't be woken.

Storing it

Store at room temperature, away from heat and moisture (not in the bathroom), and out of reach of children and pets.

Conditions it's used for

Sources

Last updated 2026-11-13.