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Triamterene and hydrochlorothiazide

Brand names: Maxzide, Dyazide

Triamterene-HCTZ is a water pill combination that lowers blood pressure and reduces swelling while keeping potassium from dropping.

Brand namesMaxzide, Dyazide
Type of medicineDiuretic combination (water pill)
Prescription?Prescription
ImportantThis page is general information, not a prescription. Don't start, stop, or change a medicine without talking to your provider or pharmacist.

Overview

Triamterene saves potassium; hydrochlorothiazide removes salt and water.

What it's used for

  • High blood pressure
  • Fluid buildup (edema)

How to take it

  • Take it in the morning, with food.
  • Don't take potassium supplements unless your provider says to.

Your dose depends on your health and other medicines. Always follow your prescription label, and ask your pharmacist if anything is unclear.

Side effects

Common side effects

  • Peeing more
  • Dizziness
  • Muscle cramps
  • Sun sensitivity
Call 911A slow or irregular heartbeat, muscle weakness, or tingling (possible high potassium)
Call your provider todayExtreme thirst, confusion, or very little urine
Call your provider todaySevere side pain (kidney stone)

Warnings

  • Boxed warning: high potassium, more likely with kidney disease, diabetes, or older age.
  • Your provider will check potassium and kidney function.

Other medicines, foods, and alcohol

  • Potassium supplements, salt substitutes, ACE inhibitors, ARBs, and spironolactone raise potassium.
  • Lithium levels can rise.
  • NSAIDs can harm the kidneys.

Tell your provider and pharmacist about every medicine, vitamin, and supplement you take.

Pregnancy and breastfeeding

Usually not a first choice in pregnancy.

Missed doses, overdose, and storage

If you miss a dose

Take it as soon as you remember, unless it's almost time for your next dose. Then skip the missed dose. Don't take two doses at once.

If someone takes too much

Call Poison Control at 1-800-222-1222 or get help online at poison.org. Call 911 if the person collapses, has a seizure, has trouble breathing, or can't be woken.

Storing it

Store at room temperature, away from heat and moisture (not in the bathroom), and out of reach of children and pets.

Conditions it's used for

Sources

Last updated 2026-11-13.