Overview
Triamterene saves potassium; hydrochlorothiazide removes salt and water.
What it's used for
- High blood pressure
- Fluid buildup (edema)
How to take it
- Take it in the morning, with food.
- Don't take potassium supplements unless your provider says to.
Your dose depends on your health and other medicines. Always follow your prescription label, and ask your pharmacist if anything is unclear.
Side effects
Common side effects
- Peeing more
- Dizziness
- Muscle cramps
- Sun sensitivity
Warnings
- Boxed warning: high potassium, more likely with kidney disease, diabetes, or older age.
- Your provider will check potassium and kidney function.
Other medicines, foods, and alcohol
- Potassium supplements, salt substitutes, ACE inhibitors, ARBs, and spironolactone raise potassium.
- Lithium levels can rise.
- NSAIDs can harm the kidneys.
Tell your provider and pharmacist about every medicine, vitamin, and supplement you take.
Pregnancy and breastfeeding
Usually not a first choice in pregnancy.
Missed doses, overdose, and storage
If you miss a dose
Take it as soon as you remember, unless it's almost time for your next dose. Then skip the missed dose. Don't take two doses at once.
If someone takes too much
Call Poison Control at 1-800-222-1222 or get help online at poison.org. Call 911 if the person collapses, has a seizure, has trouble breathing, or can't be woken.
Storing it
Store at room temperature, away from heat and moisture (not in the bathroom), and out of reach of children and pets.
Conditions it's used for
Sources
- DailyMed: FDA drug label for Triamterene and hydrochlorothiazide (U.S. National Library of Medicine)
- MedlinePlus: Drugs, herbs, and supplements
- FDA: Drugs@FDA
Last updated 2026-11-13.