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Zuranolone

Brand names: Zurzuvae

Zuranolone is a 14-day pill treatment for postpartum depression.

Brand namesZurzuvae
Type of medicineNeurosteroid (postpartum depression medicine)
Prescription?Prescription
ImportantThis page is general information, not a prescription. Don't start, stop, or change a medicine without talking to your provider or pharmacist.

Overview

It works faster than standard antidepressants.

What it's used for

  • Postpartum depression

How to take it

  • Take it once a day in the evening with a fat-containing meal for 14 days.
  • Don't drive for at least 12 hours after each dose.

Your dose depends on your health and other medicines. Always follow your prescription label, and ask your pharmacist if anything is unclear.

Side effects

Common side effects

  • Sleepiness
  • Dizziness
  • Tiredness
Call 911Thoughts of suicide or harming yourself. Call or text 988 any time.
Call your provider todayConfusion or extreme sleepiness

Warnings

  • Boxed warning: impaired driving.

Other medicines, foods, and alcohol

  • Alcohol and sedating medicines add to drowsiness.
  • Strong CYP3A4 drugs change its level.

Tell your provider and pharmacist about every medicine, vitamin, and supplement you take.

Pregnancy and breastfeeding

It can harm an unborn baby; use birth control during and for 1 week after. Ask about breastfeeding.

Missed doses, overdose, and storage

If you miss a dose

Take it as soon as you remember, unless it's almost time for your next dose. Then skip the missed dose. Don't take two doses at once.

If someone takes too much

Call Poison Control at 1-800-222-1222 or get help online at poison.org. Call 911 if the person collapses, has a seizure, has trouble breathing, or can't be woken.

Storing it

Store at room temperature, away from heat and moisture (not in the bathroom), and out of reach of children and pets.

Conditions it's used for

Sources

Last updated 2026-11-13.