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Anion gap

Also called: AG

The anion gap is a calculation from sodium, chloride, and bicarbonate. A high gap can point to a buildup of acid in the blood.

SampleA small tube of blood from a vein in your arm
Fasting?Usually not needed
ResultsOften the same day
Good to knowOne result rarely tells the whole story. Your provider looks at your results together with your symptoms, exam, and other tests.

What the test is

It's calculated from basic metabolic panel results; no separate test is needed.

Why it's done

  • Checking acid-base balance in very sick patients

Getting ready and what happens

  • None.

How the test is done

  • Calculated from a metabolic panel.

What the results mean

ResultTypical range for adults
Anion gapAbout 4 to 12 mEq/L (depends on the lab's method)

Normal ranges vary from lab to lab and can differ by age, sex, and pregnancy. Your report lists your lab's own range next to each result. A result a little outside the range is often not a problem.

High

Can come from diabetic ketoacidosis, lactic acidosis, kidney failure, or some poisonings.

Questions to ask your provider

  • What do my results mean for me?
  • Do I need to repeat this test or have other tests?

Risks

A blood draw is very safe. You may have slight pain or a small bruise where the needle went in.

Related conditions

Related tests

Sources

Last updated 2026-11-13.