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Anti-dsDNA antibody

Also called: Anti-double-stranded DNA

Anti-dsDNA is an antibody that's quite specific for lupus. Levels can rise with lupus kidney disease flares.

SampleA small tube of blood from a vein in your arm
Fasting?Usually not needed
ResultsSeveral days
Good to knowOne result rarely tells the whole story. Your provider looks at your results together with your symptoms, exam, and other tests.

What the test is

It's usually checked after a positive ANA.

Why it's done

  • Positive ANA with lupus symptoms
  • Monitoring lupus activity

Getting ready and what happens

  • No preparation is needed.

How the test is done

  • A health worker cleans the skin, puts a band around your arm, and draws blood from a vein with a small needle. It takes a few minutes.

What the results mean

Positive

Strongly supports lupus with matching symptoms.

Questions to ask your provider

  • What do my results mean for me?
  • Do I need to repeat this test or have other tests?

Risks

A blood draw is very safe. You may have slight pain or a small bruise where the needle went in.

Related conditions

Related medicines

Related tests

Sources

Last updated 2026-11-13.