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Erythropoietin (EPO) test

Also called: EPO level

EPO is a kidney hormone that tells the marrow to make red blood cells. The test helps explain anemia or too many red cells.

SampleA small tube of blood from a vein in your arm
Fasting?Usually not needed
ResultsSeveral days
Good to knowOne result rarely tells the whole story. Your provider looks at your results together with your symptoms, exam, and other tests.

What the test is

Kidney disease lowers EPO.

Why it's done

  • High red blood cell counts
  • Anemia with kidney disease

Getting ready and what happens

  • None.

How the test is done

  • A health worker cleans the skin, puts a band around your arm, and draws blood from a vein with a small needle. It takes a few minutes.

What the results mean

Low with high red cells

Suggests polycythemia vera.

High with high red cells

Suggests low oxygen (smoking, sleep apnea, lung disease) or, rarely, a tumor.

Questions to ask your provider

  • What do my results mean for me?
  • Do I need to repeat this test or have other tests?

Risks

A blood draw is very safe. You may have slight pain or a small bruise where the needle went in.

Related conditions

Related tests

Sources

Last updated 2026-11-13.