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Adalimumab

Brand names: Humira, Amjevita, Hadlima, Hyrimoz, Cyltezo, Yusimry

Adalimumab is a self-injected biologic that calms the immune system. It treats rheumatoid arthritis, psoriasis, Crohn's, ulcerative colitis, and more.

Brand namesHumira, Amjevita, Hadlima, Hyrimoz, Cyltezo, Yusimry
Type of medicineBiologic (TNF blocker)
Prescription?Prescription
ImportantThis page is general information, not a prescription. Don't start, stop, or change a medicine without talking to your provider or pharmacist.

Overview

It blocks TNF, a protein that drives inflammation. Many biosimilar versions are available.

What it's used for

  • Rheumatoid and psoriatic arthritis
  • Psoriasis
  • Crohn's disease and ulcerative colitis
  • Ankylosing spondylitis
  • Hidradenitis suppurativa
  • Uveitis

How to take it

  • Inject under the skin as scheduled, often every other week.
  • Let it reach room temperature before injecting. Rotate spots.
  • You'll be tested for TB and hepatitis B before starting.

Your dose depends on your health and other medicines. Always follow your prescription label, and ask your pharmacist if anything is unclear.

Side effects

Common side effects

  • Redness or itching at the shot site
  • Colds and sinus infections
  • Headache
Call 911Trouble breathing, or swelling of the face or throat
Call your provider todayFever, chills, cough, weight loss, or night sweats (possible serious infection or TB)
Call your provider todayNew rash on the cheeks and arms that worsens in the sun, with joint pain
Call your provider todayUnusual bruising, bleeding, or paleness

Warnings

  • Boxed warnings: serious infections, including TB, and rare cancers like lymphoma.
  • Avoid live vaccines.

Other medicines, foods, and alcohol

  • Don't combine with other biologics like anakinra or abatacept.

Tell your provider and pharmacist about every medicine, vitamin, and supplement you take.

Pregnancy and breastfeeding

Often continued in pregnancy for some conditions. Talk with your provider.

Missed doses, overdose, and storage

If you miss a dose

Inject it as soon as you remember, then go back to your usual schedule. Ask your provider if unsure.

If someone takes too much

Call Poison Control at 1-800-222-1222 or get help online at poison.org. Call 911 if the person collapses, has a seizure, has trouble breathing, or can't be woken.

Storing it

Keep in the refrigerator in the original carton; don't freeze. It can be kept at room temperature for up to 14 days (check your brand).

Conditions it's used for

Sources

Last updated 2026-11-13.