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Adapalene

Brand names: Differin, Epiduo (with benzoyl peroxide)

Adapalene (Differin) is a retinoid gel that unclogs pores and prevents acne.

Brand namesDifferin, Epiduo (with benzoyl peroxide)
Type of medicineTopical retinoid
Prescription?Over the counter (0.1% gel)
ImportantThis page is general information, not a prescription. Don't start, stop, or change a medicine without talking to your provider or pharmacist.

Overview

Skin may get dry or briefly worse before it improves. Full results take about 3 months.

What it's used for

  • Acne

How to take it

  • Apply a pea-sized amount to the whole face at night after washing.
  • Use moisturizer and daily sunscreen.

Your dose depends on your health and other medicines. Always follow your prescription label, and ask your pharmacist if anything is unclear.

Side effects

Common side effects

  • Dryness
  • Redness
  • Peeling
  • Stinging
Call your provider todaySevere burning, swelling, or blistering

Warnings

  • Avoid waxing treated skin.

Other medicines, foods, and alcohol

  • Other drying products add to irritation.

Tell your provider and pharmacist about every medicine, vitamin, and supplement you take.

Pregnancy and breastfeeding

Ask your provider; topical retinoids are usually avoided in pregnancy.

Missed doses, overdose, and storage

If you miss a dose

Apply it when you remember, then go back to your usual schedule. Don't apply extra to make up for it.

If someone takes too much

Call Poison Control at 1-800-222-1222 or get help online at poison.org. Call 911 if the person collapses, has a seizure, has trouble breathing, or can't be woken.

Storing it

Store at room temperature, away from heat and moisture (not in the bathroom), and out of reach of children and pets.

Conditions it's used for

Sources

Last updated 2026-11-13.