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Tretinoin

Brand names: Retin-A, Altreno, Atralin

Tretinoin is a vitamin A cream or gel that unclogs pores to treat acne and smooths sun-damaged skin.

Brand namesRetin-A, Altreno, Atralin
Type of medicineTopical retinoid
Prescription?Prescription
ImportantThis page is general information, not a prescription. Don't start, stop, or change a medicine without talking to your provider or pharmacist.

Overview

Skin may get worse for the first few weeks before it improves. Full results take 2 to 3 months.

What it's used for

  • Acne
  • Fine wrinkles and rough skin from sun damage (some products)

How to take it

  • At night, wait 20 to 30 minutes after washing, then apply a pea-sized amount to the whole area (not just spots).
  • Use a moisturizer and sunscreen every day.
  • Avoid the corners of the nose, eyes, and mouth.

Your dose depends on your health and other medicines. Always follow your prescription label, and ask your pharmacist if anything is unclear.

Side effects

Common side effects

  • Dryness, peeling, redness, and stinging
  • Sunburning easily
Call your provider todaySevere burning, blistering, crusting, or swelling

Warnings

  • Avoid waxing treated skin.
  • Harsh soaps, astringents, and other drying acne products add to irritation.

Other medicines, foods, and alcohol

  • Benzoyl peroxide can break down some forms; apply at different times unless your product says otherwise.

Tell your provider and pharmacist about every medicine, vitamin, and supplement you take.

Pregnancy and breastfeeding

Avoid in pregnancy. Ask your provider about other acne options.

Missed doses, overdose, and storage

If you miss a dose

Apply it when you remember, then go back to your usual schedule. Don't apply extra to make up for it.

If someone takes too much

Call Poison Control at 1-800-222-1222 or get help online at poison.org. Call 911 if the person collapses, has a seizure, has trouble breathing, or can't be woken.

Storing it

Store at room temperature, away from heat and moisture (not in the bathroom), and out of reach of children and pets.

Conditions it's used for

Sources

Last updated 2026-11-13.