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Baclofen

Brand names: Lioresal, Ozobax, Fleqsuvy, Lyvispah

Baclofen relaxes tight, stiff muscles (spasticity) from multiple sclerosis or spinal cord problems.

Brand namesLioresal, Ozobax, Fleqsuvy, Lyvispah
Type of medicineMuscle relaxant
Prescription?Prescription
ImportantThis page is general information, not a prescription. Don't start, stop, or change a medicine without talking to your provider or pharmacist.

Overview

It acts on the spinal cord. It's sometimes given through a pump into the spine.

What it's used for

  • Spasticity from multiple sclerosis
  • Spasticity from spinal cord injury or disease
  • Off-label: hiccups that won't stop, alcohol use disorder

How to take it

  • Take it with or without food, spread through the day.
  • Don't stop suddenly. Stopping fast can cause seizures, hallucinations, high fever, and muscle stiffness.

Your dose depends on your health and other medicines. Always follow your prescription label, and ask your pharmacist if anything is unclear.

Side effects

Common side effects

  • Sleepiness
  • Dizziness
  • Weakness
  • Tiredness
  • Nausea
Call 911Seizure, hallucinations, high fever, or very stiff muscles after stopping or missing doses
Call 911Slow, shallow, or stopped breathing, blue lips, or can't be woken up
Call your provider todayConfusion

Warnings

  • Boxed warning (pump): stopping suddenly can be life-threatening.
  • Doses are lower with kidney disease.

Other medicines, foods, and alcohol

  • Alcohol, opioids, and other sedating medicines add to drowsiness and slowed breathing.

Tell your provider and pharmacist about every medicine, vitamin, and supplement you take.

Pregnancy and breastfeeding

Talk with your provider.

Missed doses, overdose, and storage

If you miss a dose

Take it as soon as you remember, unless it's almost time for your next dose. Then skip the missed dose. Don't take two doses at once.

If someone takes too much

Call Poison Control at 1-800-222-1222 or get help online at poison.org. Call 911 if the person collapses, has a seizure, has trouble breathing, or can't be woken.

Storing it

Store at room temperature, away from heat and moisture (not in the bathroom), and out of reach of children and pets.

Conditions it's used for

Sources

Last updated 2026-11-13.