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Cyclobenzaprine

Brand names: Flexeril, Amrix

Cyclobenzaprine is a muscle relaxant used for a short time to ease painful muscle spasms from strains and injuries.

Brand namesFlexeril, Amrix
Type of medicineMuscle relaxant
Prescription?Prescription
ImportantThis page is general information, not a prescription. Don't start, stop, or change a medicine without talking to your provider or pharmacist.

Overview

It acts on the brain and spinal cord. It's usually used for 2 to 3 weeks along with rest and physical therapy.

What it's used for

  • Painful muscle spasms from strains, sprains, and back injuries

How to take it

  • Take it with or without food.
  • It often causes sleepiness, so many people take it at night.

Your dose depends on your health and other medicines. Always follow your prescription label, and ask your pharmacist if anything is unclear.

Side effects

Common side effects

  • Sleepiness
  • Dry mouth
  • Dizziness
  • Tiredness
  • Constipation
Call 911Agitation, fever, sweating, muscle twitching or stiffness, fast heartbeat, and confusion (possible serotonin syndrome)
Call 911Chest pain, a fast or irregular heartbeat, or fainting
Call your provider todayTrouble peeing

Warnings

  • Not for people recovering from a heart attack or with heart rhythm problems or an overactive thyroid.
  • Don't drive until you know how it affects you.
  • Older adults are more likely to become confused or fall.

Other medicines, foods, and alcohol

  • Never take within 14 days of an MAOI.
  • Alcohol and other sedating medicines add to drowsiness.
  • Antidepressants, tramadol, and other serotonin medicines raise the risk of serotonin syndrome.

Tell your provider and pharmacist about every medicine, vitamin, and supplement you take.

Pregnancy and breastfeeding

Talk with your provider.

Missed doses, overdose, and storage

If you miss a dose

This medicine is often taken only when needed. If you take it on a schedule, take a missed dose when you remember, unless it's almost time for the next one. Don't double up.

If someone takes too much

Call Poison Control at 1-800-222-1222 or get help online at poison.org. Call 911 if the person collapses, has a seizure, has trouble breathing, or can't be woken.

Storing it

Store at room temperature, away from heat and moisture (not in the bathroom), and out of reach of children and pets.

Conditions it's used for

Sources

Last updated 2026-11-13.