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Diphenoxylate and atropine

Brand names: Lomotil

Lomotil is a prescription medicine that slows the gut to control diarrhea.

Brand namesLomotil
Type of medicineAnti-diarrhea medicine
Prescription?Prescription
ImportantThis page is general information, not a prescription. Don't start, stop, or change a medicine without talking to your provider or pharmacist.

Overview

Atropine is added in a small amount to discourage misuse.

What it's used for

  • Diarrhea (with fluids and diet)

How to take it

  • Take as directed and stop once diarrhea is controlled.
  • Drink plenty of fluids.

Your dose depends on your health and other medicines. Always follow your prescription label, and ask your pharmacist if anything is unclear.

Side effects

Common side effects

  • Dry mouth
  • Dizziness
  • Sleepiness
Call 911A child swallowed any amount (it can slow breathing hours later)
Call your provider todaySwollen, painful belly

Warnings

  • Not for children under 6.
  • Don't use with bloody diarrhea, high fever, or C. diff.

Other medicines, foods, and alcohol

  • Alcohol and sedating medicines add to drowsiness.
  • Never take within 14 days of an MAOI.

Tell your provider and pharmacist about every medicine, vitamin, and supplement you take.

Pregnancy and breastfeeding

Talk with your provider.

Missed doses, overdose, and storage

If you miss a dose

This medicine is often taken only when needed. If you take it on a schedule, take a missed dose when you remember, unless it's almost time for the next one. Don't double up.

If someone takes too much

Call Poison Control at 1-800-222-1222 or get help online at poison.org. Call 911 if the person collapses, has a seizure, has trouble breathing, or can't be woken.

Storing it

Store at room temperature, away from heat and moisture (not in the bathroom), and out of reach of children and pets.

Conditions it's used for

Sources

Last updated 2026-11-13.