ImportantThis page is general information, not a prescription. Don't start, stop, or change a medicine without talking to your provider or pharmacist.
Overview
Treated areas get red, crusty, and sore before they heal over a few weeks.
What it's used for
- Actinic keratosis
- Superficial basal cell carcinoma
How to take it
- Apply as directed for 2 to 4 weeks, then let the skin heal.
- Wash your hands well after; avoid eyes, nose, and mouth.
- Stay out of the sun.
Your dose depends on your health and other medicines. Always follow your prescription label, and ask your pharmacist if anything is unclear.
Side effects
Common side effects
- Redness, crusting, burning, and soreness
Call 911Severe vomiting, diarrhea, mouth sores, or fever (rare severe reaction in people with DPD deficiency)
Warnings
- Keep it away from pets; small amounts can be deadly to dogs.
Other medicines, foods, and alcohol
- None known.
Tell your provider and pharmacist about every medicine, vitamin, and supplement you take.
Pregnancy and breastfeeding
Not used in pregnancy.
Missed doses, overdose, and storage
If you miss a dose
Apply it when you remember, then go back to your usual schedule. Don't apply extra to make up for it.
If someone takes too much
Call Poison Control at 1-800-222-1222 or get help online at poison.org. Call 911 if the person collapses, has a seizure, has trouble breathing, or can't be woken.
Storing it
Store at room temperature, away from heat and moisture (not in the bathroom), and out of reach of children and pets.
Conditions it's used for
Sources
- DailyMed: FDA drug label for Fluorouracil cream (U.S. National Library of Medicine)
- MedlinePlus: Drugs, herbs, and supplements
- FDA: Drugs@FDA
Last updated 2026-11-13.