Naloxone

Overview

It quickly blocks opioids in the brain and can restore breathing. It does nothing to someone who hasn't taken opioids, so it's safe to give if you're unsure.

Signs of opioid overdose: can't be woken, slow or no breathing, blue or gray lips, pinpoint pupils.

What it's used for

• Emergency treatment of a known or suspected opioid overdose

How to take it

• Call 911.
• Lay the person on their back, insert the nozzle into a nostril, and press the plunger.
• If they don't respond in 2 to 3 minutes, give a second dose in the other nostril with a new device.
• Give rescue breaths if trained, then roll them onto their side. Stay with them; it can wear off before the opioid does.

Your dose depends on your health and other medicines. Always follow your prescription label, and ask your pharmacist if anything is unclear.

Side effects

Common side effects

• Sudden opioid withdrawal: body aches, sweating, nausea, fast heartbeat, agitation

Warnings

• It may need repeat doses for strong opioids like fentanyl.
• Check the expiration date and keep it at room temperature.

Other medicines, foods, and alcohol

• It blocks the effects of opioid pain medicines.

Tell your provider and pharmacist about every medicine, vitamin, and supplement you take.

Pregnancy and breastfeeding

Give it to a pregnant person having an overdose. Saving the parent's life comes first.

Missed doses, overdose, and storage

If you miss a dose

Not applicable: naloxone is only used in an emergency.

If someone takes too much

Call Poison Control at 1-800-222-1222 or get help online at poison.org. Call 911 if the person collapses, has a seizure, has trouble breathing, or can't be woken.

Storing it

Keep it at room temperature in its box, where family and friends can find it quickly. Replace it before it expires.

Conditions it's used for

• Opioid use and dependence