Overview
Norethindrone pills must be taken within the same 3-hour window every day. Opill is a similar over-the-counter pill.
What it's used for
- Preventing pregnancy
How to take it
- Take one pill every day at the same time, with no break between packs.
- Use backup (like condoms) for 48 hours if you take one more than 3 hours late.
Your dose depends on your health and other medicines. Always follow your prescription label, and ask your pharmacist if anything is unclear.
Side effects
Common side effects
- Irregular bleeding or spotting
- Headache
- Breast tenderness
Warnings
- It doesn't protect against STIs.
- Not for people with breast cancer.
Other medicines, foods, and alcohol
- Rifampin, some seizure medicines, St. John's wort, and some HIV medicines make it less effective.
Tell your provider and pharmacist about every medicine, vitamin, and supplement you take.
Pregnancy and breastfeeding
Stop if pregnant. Fine while breastfeeding.
Missed doses, overdose, and storage
If you miss a dose
If you're more than 3 hours late, take it as soon as you remember, keep going, and use backup birth control for the next 48 hours. Consider emergency contraception if you had sex recently.
If someone takes too much
Call Poison Control at 1-800-222-1222 or get help online at poison.org. Call 911 if the person collapses, has a seizure, has trouble breathing, or can't be woken.
Storing it
Store at room temperature, away from heat and moisture (not in the bathroom), and out of reach of children and pets.
Conditions it's used for
Sources
- DailyMed: FDA drug label for Norethindrone (progestin-only pill) (U.S. National Library of Medicine)
- MedlinePlus: Drugs, herbs, and supplements
- FDA: Drugs@FDA
Last updated 2026-11-13.