Overview
Phenylephrine nasal spray and pseudoephedrine pills do relieve congestion. The FDA has proposed removing oral phenylephrine from over-the-counter products.
What it's used for
- Stuffy nose (nasal spray)
How to take it
- Follow the label.
- Ask a pharmacist about better options for congestion.
Your dose depends on your health and other medicines. Always follow your prescription label, and ask your pharmacist if anything is unclear.
Side effects
Common side effects
- Nervousness
- Trouble sleeping
- Headache
Warnings
- Ask a provider first if you have high blood pressure or heart disease.
- Nasal spray: don't use more than 3 days in a row.
Other medicines, foods, and alcohol
- Never take within 14 days of an MAOI.
Tell your provider and pharmacist about every medicine, vitamin, and supplement you take.
Pregnancy and breastfeeding
Ask your provider.
Missed doses, overdose, and storage
If you miss a dose
This medicine is often taken only when needed. If you take it on a schedule, take a missed dose when you remember, unless it's almost time for the next one. Don't double up.
If someone takes too much
Call Poison Control at 1-800-222-1222 or get help online at poison.org. Call 911 if the person collapses, has a seizure, has trouble breathing, or can't be woken.
Storing it
Store at room temperature, away from heat and moisture (not in the bathroom), and out of reach of children and pets.
Conditions it's used for
Sources
- DailyMed: FDA drug label for Phenylephrine (U.S. National Library of Medicine)
- MedlinePlus: Drugs, herbs, and supplements
- FDA: Drugs@FDA
Last updated 2026-11-13.