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Roflumilast

Brand names: Daliresp, Zoryve (cream and foam)

Roflumilast pills lower COPD flare-ups in people with chronic bronchitis. The cream and foam treat psoriasis and seborrheic dermatitis.

Brand namesDaliresp, Zoryve (cream and foam)
Type of medicinePDE4 inhibitor
Prescription?Prescription
ImportantThis page is general information, not a prescription. Don't start, stop, or change a medicine without talking to your provider or pharmacist.

Overview

The pill isn't a bronchodilator and doesn't relieve sudden symptoms.

What it's used for

  • Preventing COPD flares (pills)
  • Psoriasis and seborrheic dermatitis (topical)

How to take it

  • Pills: take once a day, with or without food.

Your dose depends on your health and other medicines. Always follow your prescription label, and ask your pharmacist if anything is unclear.

Side effects

Common side effects

  • Diarrhea
  • Weight loss
  • Nausea
  • Headache
Call 911Thoughts of suicide or harming yourself. Call or text 988 any time.
Call your provider todayUnintended weight loss

Warnings

  • Not for people with moderate to severe liver disease.

Other medicines, foods, and alcohol

  • Rifampin and some seizure medicines lower its effect.

Tell your provider and pharmacist about every medicine, vitamin, and supplement you take.

Pregnancy and breastfeeding

Talk with your provider.

Missed doses, overdose, and storage

If you miss a dose

Take it as soon as you remember, unless it's almost time for your next dose. Then skip the missed dose. Don't take two doses at once.

If someone takes too much

Call Poison Control at 1-800-222-1222 or get help online at poison.org. Call 911 if the person collapses, has a seizure, has trouble breathing, or can't be woken.

Storing it

Store at room temperature, away from heat and moisture (not in the bathroom), and out of reach of children and pets.

Conditions it's used for

Sources

Last updated 2026-11-13.