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Upadacitinib

Brand names: Rinvoq

Upadacitinib is a once-daily pill for rheumatoid arthritis, eczema, Crohn's disease, ulcerative colitis, and more.

Brand namesRinvoq
Type of medicineJAK inhibitor
Prescription?Prescription
ImportantThis page is general information, not a prescription. Don't start, stop, or change a medicine without talking to your provider or pharmacist.

Overview

It's used when other treatments haven't worked.

What it's used for

  • Rheumatoid and psoriatic arthritis
  • Moderate to severe eczema
  • Crohn's disease and ulcerative colitis
  • Ankylosing spondylitis

How to take it

  • Swallow tablets whole once a day.

Your dose depends on your health and other medicines. Always follow your prescription label, and ask your pharmacist if anything is unclear.

Side effects

Common side effects

  • Colds
  • Acne
  • Nausea
  • Higher cholesterol
Call your provider todayFever, chills, sore throat, or other signs of infection
Call 911Chest pain or signs of a stroke
Call your provider todayPain or swelling in one leg, or sudden shortness of breath

Warnings

  • Boxed warnings: serious infections, death, cancers, heart attacks and strokes, and blood clots, especially in people over 50 with heart risks or who smoke.
  • You'll be tested for TB and hepatitis B before starting. Avoid live vaccines.

Other medicines, foods, and alcohol

  • Strong CYP3A4 drugs change its level.
  • Avoid grapefruit.

Tell your provider and pharmacist about every medicine, vitamin, and supplement you take.

Pregnancy and breastfeeding

It can harm an unborn baby; use birth control.

Missed doses, overdose, and storage

If you miss a dose

Take it as soon as you remember, unless it's almost time for your next dose. Then skip the missed dose. Don't take two doses at once.

If someone takes too much

Call Poison Control at 1-800-222-1222 or get help online at poison.org. Call 911 if the person collapses, has a seizure, has trouble breathing, or can't be woken.

Storing it

Store at room temperature, away from heat and moisture (not in the bathroom), and out of reach of children and pets.

Conditions it's used for

Sources

Last updated 2026-11-13.