Overview
Gout causes sudden, intense pain, redness, and swelling, often in the big toe, ankle, or knee, frequently starting at night. Pseudogout is similar and often affects the knee or wrist in older adults.
Septic arthritis is a bacterial infection inside a joint. It usually affects one joint, often the knee, with fever and severe pain moving the joint. It's more likely with diabetes, joint replacements, injected drug use, and recent joint injections.
When to get medical care
Causes
Causes include gout, pseudogout, septic arthritis, injury and bleeding into the joint, reactive arthritis after infections, Lyme disease, rheumatoid arthritis, and psoriatic arthritis.
OwieClear has pages on 3 conditions that can cause red, hot, swollen joint. Each shows how soon to get care.
Common causes
- GoutOften needs care today
A type of arthritis caused by uric acid crystals in a joint.
- Joint infection (septic arthritis)Often needs care today
A bacterial infection inside a joint.
- Pseudogout (CPPD)Often needs care today
Calcium crystals in a joint cause sudden attacks of pain, swelling, warmth, and redness, most often in the knee or wrist, like gout.
What you can do at home
- Rest and raise the joint.
- Ice for 15 to 20 minutes at a time.
- Drink water.
- Avoid alcohol during a gout flare.
Medicines
Gout is treated with NSAIDs, colchicine, or steroids. Joint infections need drainage and IV antibiotics. Don't take leftover steroids for a hot joint until infection is ruled out.
At the doctor
Fluid from the joint shows whether it's infection or crystals.
Questions you may be asked
- When it started
- Fever
- Past gout
- Injury, cuts, or injections
- Diabetes or artificial joints
The exam
A joint exam.
Tests
- Joint fluid test for crystals and infection
- Blood tests
- X-rays
Prevention
You can lower your risk.
- Limit alcohol and sugary drinks if you have gout
- Take uric acid medicine as prescribed
- Treat skin wounds
Check your symptoms
Most symptoms have more than one possible cause. The symptom checker looks at all of your symptoms together, plus your age, and shows how soon to get care.
Sources
Last updated 2026-11-13.