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C. diff test

Also called: Clostridioides difficile test, C. difficile toxin test

The C. diff test checks diarrhea for a germ that can cause severe colitis, especially after antibiotics.

SampleA stool sample
Fasting?Usually not needed
Results1 to 2 days
Good to knowOne result rarely tells the whole story. Your provider looks at your results together with your symptoms, exam, and other tests.

What the test is

Only watery stool is tested.

Why it's done

  • Three or more watery stools a day during or after antibiotics or a hospital stay

Getting ready and what happens

  • Don't take anti-diarrhea medicine before testing.

How the test is done

  • You collect a liquid stool sample.

What the results mean

Positive

Treated with specific antibiotics, like oral vancomycin or fidaxomicin. Wash hands with soap and water; hand sanitizer doesn't kill C. diff spores.

When a result needs quick action

Call 911Severe belly pain or swelling, fever, or fainting with diarrhea

Questions to ask your provider

  • What do my results mean for me?
  • Do I need to repeat this test or have other tests?

Related conditions

Related medicines

Related tests

Sources

Last updated 2026-11-13.