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Fluconazole

Brand names: Diflucan

Fluconazole is an antifungal pill that treats vaginal yeast infections, thrush, and other fungal infections.

Brand namesDiflucan
Type of medicineAntifungal
Prescription?Prescription
ImportantThis page is general information, not a prescription. Don't start, stop, or change a medicine without talking to your provider or pharmacist.

Overview

A single pill often treats a vaginal yeast infection. Symptoms may take a few days to clear.

What it's used for

  • Vaginal yeast infections
  • Thrush (mouth or throat)
  • Other fungal infections

How to take it

  • Take it with or without food.
  • If symptoms aren't better in a few days, or come back often, see your provider.

Your dose depends on your health and other medicines. Always follow your prescription label, and ask your pharmacist if anything is unclear.

Side effects

Common side effects

  • Headache
  • Nausea
  • Stomach pain
  • Change in taste
Call 911Fainting or a fast, irregular heartbeat
Call 911A blistering, peeling, or widespread red rash, especially with fever
Call your provider todayYellow skin or eyes or dark urine

Warnings

  • Tell your provider about heart rhythm or liver problems.

Other medicines, foods, and alcohol

  • It raises levels of many medicines, including warfarin, some statins, some diabetes pills, and phenytoin.
  • Other medicines that affect heart rhythm add to that risk.

Tell your provider and pharmacist about every medicine, vitamin, and supplement you take.

Pregnancy and breastfeeding

Avoid in pregnancy unless your provider says so; higher doses are linked to birth defects. Creams are usually used instead.

Missed doses, overdose, and storage

If you miss a dose

Take it as soon as you remember. If it's almost time for the next dose, skip the missed one. Don't double up, and still finish the full course.

If someone takes too much

Call Poison Control at 1-800-222-1222 or get help online at poison.org. Call 911 if the person collapses, has a seizure, has trouble breathing, or can't be woken.

Storing it

Store at room temperature, away from heat and moisture (not in the bathroom), and out of reach of children and pets.

Conditions it's used for

Sources

Last updated 2026-11-13.