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Itraconazole

Brand names: Sporanox, Tolsura

Itraconazole treats nail fungus and serious fungal infections. It interacts with many medicines.

Brand namesSporanox, Tolsura
Type of medicineAntifungal
Prescription?Prescription
ImportantThis page is general information, not a prescription. Don't start, stop, or change a medicine without talking to your provider or pharmacist.

Overview

Capsules and liquid are absorbed differently.

What it's used for

  • Nail fungus
  • Lung and other serious fungal infections

How to take it

  • Capsules: take with a full meal. Liquid: take on an empty stomach.

Your dose depends on your health and other medicines. Always follow your prescription label, and ask your pharmacist if anything is unclear.

Side effects

Common side effects

  • Nausea
  • Headache
  • Rash
Call your provider todayShortness of breath, swelling, or fast weight gain (heart failure)
Call your provider todayYellow skin or eyes, dark urine, or pain in the upper right belly

Warnings

  • Boxed warnings: heart failure and dangerous drug interactions.

Other medicines, foods, and alcohol

  • Many medicines must not be combined, including some statins, some heart rhythm medicines, and certain sedatives.

Tell your provider and pharmacist about every medicine, vitamin, and supplement you take.

Pregnancy and breastfeeding

Not used for nail fungus in pregnancy.

Missed doses, overdose, and storage

If you miss a dose

Take it as soon as you remember, unless it's almost time for your next dose. Then skip the missed dose. Don't take two doses at once.

If someone takes too much

Call Poison Control at 1-800-222-1222 or get help online at poison.org. Call 911 if the person collapses, has a seizure, has trouble breathing, or can't be woken.

Storing it

Store at room temperature, away from heat and moisture (not in the bathroom), and out of reach of children and pets.

Conditions it's used for

Sources

Last updated 2026-11-13.