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Pantoprazole

Brand names: Protonix

Pantoprazole is a proton pump inhibitor (PPI) that lowers stomach acid to treat acid reflux and heal the esophagus.

Brand namesProtonix
Type of medicineProton pump inhibitor (acid reducer)
Prescription?Prescription
ImportantThis page is general information, not a prescription. Don't start, stop, or change a medicine without talking to your provider or pharmacist.

Overview

It blocks the stomach's acid pumps. It's not for instant heartburn relief.

What it's used for

  • Acid reflux (GERD)
  • Healing an inflamed esophagus
  • Conditions with too much stomach acid

How to take it

  • Take tablets 30 to 60 minutes before breakfast. Swallow them whole.
  • Granules are mixed with applesauce or apple juice.

Your dose depends on your health and other medicines. Always follow your prescription label, and ask your pharmacist if anything is unclear.

Side effects

Common side effects

  • Headache
  • Diarrhea
  • Nausea or stomach pain
  • Gas
Call your provider todaySevere watery diarrhea that won't stop
Call your provider todayMuscle spasms, shakiness, or an irregular heartbeat (possible low magnesium)
Call your provider todayPeeing less or a rash with joint pain

Warnings

  • Long-term use is linked to low magnesium and B12 and bone fractures.
  • Trouble swallowing, black stools, or vomiting blood need prompt checking.

Other medicines, foods, and alcohol

  • It can change levels of methotrexate and some HIV medicines.
  • It lowers absorption of some medicines that need stomach acid.

Tell your provider and pharmacist about every medicine, vitamin, and supplement you take.

Pregnancy and breastfeeding

Talk with your provider.

Missed doses, overdose, and storage

If you miss a dose

Take it as soon as you remember, unless it's almost time for your next dose. Then skip the missed dose. Don't take two doses at once.

If someone takes too much

Call Poison Control at 1-800-222-1222 or get help online at poison.org. Call 911 if the person collapses, has a seizure, has trouble breathing, or can't be woken.

Storing it

Store at room temperature, away from heat and moisture (not in the bathroom), and out of reach of children and pets.

Conditions it's used for

Sources

Last updated 2026-11-13.