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Rabeprazole

Brand names: Aciphex

Rabeprazole is a PPI that lowers stomach acid to treat reflux and ulcers.

Brand namesAciphex
Type of medicineProton pump inhibitor (acid reducer)
Prescription?Prescription
ImportantThis page is general information, not a prescription. Don't start, stop, or change a medicine without talking to your provider or pharmacist.

Overview

It's also part of H. pylori treatment.

What it's used for

  • Acid reflux (GERD)
  • Ulcers
  • H. pylori treatment

How to take it

  • Swallow tablets whole, usually once a day.

Your dose depends on your health and other medicines. Always follow your prescription label, and ask your pharmacist if anything is unclear.

Side effects

Common side effects

  • Headache
  • Diarrhea
  • Belly pain
Call your provider todaySevere watery diarrhea
Call your provider todayMuscle cramps or irregular heartbeat (low magnesium)

Warnings

  • Long-term use is linked to low magnesium and B12 and bone fractures.

Other medicines, foods, and alcohol

  • It lowers absorption of some medicines that need stomach acid.

Tell your provider and pharmacist about every medicine, vitamin, and supplement you take.

Pregnancy and breastfeeding

Talk with your provider.

Missed doses, overdose, and storage

If you miss a dose

Take it as soon as you remember, unless it's almost time for your next dose. Then skip the missed dose. Don't take two doses at once.

If someone takes too much

Call Poison Control at 1-800-222-1222 or get help online at poison.org. Call 911 if the person collapses, has a seizure, has trouble breathing, or can't be woken.

Storing it

Store at room temperature, away from heat and moisture (not in the bathroom), and out of reach of children and pets.

Conditions it's used for

Sources

Last updated 2026-11-13.