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Factor V Leiden test

Also called: Factor V Leiden mutation, Inherited clotting tests, Prothrombin gene mutation

This genetic test checks for factor V Leiden, the most common inherited cause of a higher blood clot risk.

SampleA small tube of blood from a vein in your arm
Fasting?Usually not needed
Results1 to 2 weeks
Good to knowOne result rarely tells the whole story. Your provider looks at your results together with your symptoms, exam, and other tests.

What the test is

Many carriers never have a clot. Testing is usually limited to specific situations.

Why it's done

  • A clot at a young age or without a clear cause
  • Strong family history of clots
  • Repeated pregnancy loss

Getting ready and what happens

  • No preparation is needed.

How the test is done

  • A health worker cleans the skin, puts a band around your arm, and draws blood from a vein with a small needle. It takes a few minutes.

What the results mean

Positive

Your provider may recommend avoiding estrogen and using clot prevention during high-risk times, like surgery or pregnancy.

Questions to ask your provider

  • What do my results mean for me?
  • Do I need to repeat this test or have other tests?

Risks

A blood draw is very safe. You may have slight pain or a small bruise where the needle went in.

Related conditions

Related medicines

Related tests

Sources

Last updated 2026-11-13.