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Cetirizine

Brand names: Zyrtec

Cetirizine is a once-a-day antihistamine that relieves allergy symptoms and itchy hives.

Brand namesZyrtec
Type of medicineAntihistamine (allergy medicine)
Prescription?Over the counter
ImportantThis page is general information, not a prescription. Don't start, stop, or change a medicine without talking to your provider or pharmacist.

Overview

It blocks histamine, a chemical released during allergic reactions. It causes less drowsiness than older antihistamines like diphenhydramine, but some people still feel sleepy.

What it's used for

  • Seasonal and indoor allergies: sneezing, runny nose, and itchy eyes
  • Hives

How to take it

  • Take it once a day, with or without food.
  • For children, use the children's product and follow the label by age.
  • It works within about an hour.

Your dose depends on your health and other medicines. Always follow your prescription label, and ask your pharmacist if anything is unclear.

Side effects

Common side effects

  • Sleepiness
  • Dry mouth
  • Tiredness
  • Sore throat
Call 911Swelling of the face or throat, or trouble breathing
Call your provider todayFast or pounding heartbeat
Call your provider todayTrouble peeing

Warnings

  • Ask a provider before using it if you have kidney or liver disease.
  • Don't drive until you know whether it makes you sleepy.
  • Some people get itching after stopping it after long daily use.

Other medicines, foods, and alcohol

  • Alcohol and sedating medicines add to drowsiness.

Tell your provider and pharmacist about every medicine, vitamin, and supplement you take.

Pregnancy and breastfeeding

Ask your provider before using it in pregnancy or while breastfeeding.

Missed doses, overdose, and storage

If you miss a dose

This medicine is often taken only when needed. If you take it on a schedule, take a missed dose when you remember, unless it's almost time for the next one. Don't double up.

If someone takes too much

Call Poison Control at 1-800-222-1222 or get help online at poison.org. Call 911 if the person collapses, has a seizure, has trouble breathing, or can't be woken.

Storing it

Store at room temperature, away from heat and moisture (not in the bathroom), and out of reach of children and pets.

Conditions it's used for

Sources

Last updated 2026-11-13.