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Levocetirizine

Brand names: Xyzal

Levocetirizine is a once-daily antihistamine for allergies and hives. It's taken in the evening.

Brand namesXyzal
Type of medicineAntihistamine (allergy medicine)
Prescription?Over the counter
ImportantThis page is general information, not a prescription. Don't start, stop, or change a medicine without talking to your provider or pharmacist.

Overview

It's closely related to cetirizine and can cause some drowsiness.

What it's used for

  • Seasonal and indoor allergies
  • Hives

How to take it

  • Take it once in the evening, with or without food.
  • Follow the label for age.

Your dose depends on your health and other medicines. Always follow your prescription label, and ask your pharmacist if anything is unclear.

Side effects

Common side effects

  • Sleepiness
  • Dry mouth
  • Tiredness
  • Sore throat
Call 911Swelling of the face, lips, or throat, hives, or trouble breathing
Call your provider todayTrouble peeing

Warnings

  • Not for people with severe kidney disease.
  • Some people get itching after stopping long daily use.

Other medicines, foods, and alcohol

  • Alcohol and sedating medicines add to drowsiness.

Tell your provider and pharmacist about every medicine, vitamin, and supplement you take.

Pregnancy and breastfeeding

Ask your provider.

Missed doses, overdose, and storage

If you miss a dose

Take it as soon as you remember, unless it's almost time for your next dose. Then skip the missed dose. Don't take two doses at once.

If someone takes too much

Call Poison Control at 1-800-222-1222 or get help online at poison.org. Call 911 if the person collapses, has a seizure, has trouble breathing, or can't be woken.

Storing it

Store at room temperature, away from heat and moisture (not in the bathroom), and out of reach of children and pets.

Conditions it's used for

Sources

Last updated 2026-11-13.