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Pinpoint pupils, nodding off, or constipation from opioids

Also called: Opioid effects, overdose

Pinpoint pupils, nodding off, or constipation are effects of opioids. Slow breathing or not waking up is an overdose: give naloxone and call 911.

Common causesOpioids
Usually serious?Can be
Get checked ifSlow breathing or hard to wake
If you think it's an emergency, call 911.Thinking about suicide or in crisis? Call or text 988.Being hurt or threatened at home? National Domestic Violence Hotline: 1-800-799-7233.Help with alcohol or drug use: SAMHSA Helpline, 1-800-662-4357.

Overview

Naloxone reverses overdoses.

Help is available at 1-800-662-4357.

When to get medical care

Call 911Slow or no breathing, blue lips, or can't wake: give naloxone and call 911.
Get care todaySevere constipation or vomiting.
See a doctor soonWanting help.

Causes

Caused by opioids.

OwieClear has pages on 1 condition that can cause pinpoint pupils, nodding off, or constipation from opioids. Each shows how soon to get care.

Common causes

  • Opioid use and dependenceSee a doctor if it doesn't get better

    Regular use of pain pills, fentanyl, or heroin can cause pinpoint pupils, nodding off, constipation, itching, and needing more to get the same effect.

What you can do at home

  • Keep naloxone.
  • Don't use alone.

Medicines

Buprenorphine or methadone for opioid use disorder.

At the doctor

The provider will check.

Questions you may be asked

  • Use

The exam

A physical exam.

Tests

  • None

Prevention

Reduce harm.

  • Carry naloxone

Check your symptoms

Most symptoms have more than one possible cause. The symptom checker looks at all of your symptoms together, plus your age, and shows how soon to get care.

Start the symptom checker

Sources

Last updated 2026-11-13.